Leber's Hereditary Optic Neuropathy lhon.info



Leber's Hereditary Optic Neuropathy





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Born with a Bomb



Leber's Hereditary Optic Neuropathy


Welcome to lhon.info

This site has been created to provide a DATABASE about LHON and information regarding Leber's Hereditary Optic Neuropathy.

The site is not intended to replace the main LHON websites listed and linked below.

Second Annual LHON Symposium
June 5, 2014
Pittsburgh, PA

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Book Cover : Born with a Bomb

Leber's hereditary optic neuropathy (LHON) is a mitochondrial inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, it may appear in early childhood or later in adulthood. For unknown reasons, males are affected more often than females.

Blurring and clouding of central vision are usually the first symptoms of this disorder. These vision problems may begin in one eye or simultaneously in both eyes; if vision loss starts in one eye, the other eye is usually affected within several weeks or months. Over time, central vision in both eyes worsens with a severe loss of sharpness (visual acuity) and often affects colour vision. This condition mainly affects central vision and good peripheral vision usually remains to varying extents.  The loss of central vision creates difficulties for detailed tasks such as reading, driving, and recognizing faces.  Vision loss results from the death of retinal ganglion cells in the nerves that relay visual information from the eyes to the brain. Although central vision gradually improves in a small percentage of cases, in most cases the vision loss is profound and permanent and those affected are legally blind.

Painless central vision loss of is typically the only symptom of Leber's hereditary optic neuropathy; however, some families with other signs and symptoms have been reported.

Please take the time to complete our database if you are affected or you can fill in the database for an affected family member, loved one or friend.

And visit some of the websites below or on our links page to find out more about Leber's Hereditary Optic Neuropathy.


Patient Booklet

A simple and concise pamphlet about LHON by Jim Leeder

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New Book compiled by

Valerie Byrne Rudisill

Now Available





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Audio Format

available from

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